Hi Arun,
It will depend on your requirement..what actions / logic you need to define:
1. Do you want the Entire file to fail if it contains that 2 fields?
---> If yes, you can do it in Message Mapping / Receiver Determination condn check
2. Do you just want to Suppress the Records having those 2 fields and process the rest?
--> If yes, you can achieve this in Message Mapping as suggested above
3. Do you want to pass the records with that 2 fields into a separate message?
---> If yes, you can achieve this using Receiver Determination and pass those records to some other Receiver / Interface based on the conditions
Hope it helps
Regards,
Azhar